"I am against foreign intervention by force in what happens in Syria," Morsi said in an interview with American television PBS on Monday.
"I do not condone this and I think that it is a big mistake if it happens," he added through an interpreter. "Egypt does not agree to this."
The Egyptian president noted that his proposed diplomatic quartet which includes Egypt, Iran, Saudi Arabia and Turkey could find a diplomatic solution to the 18-month-old unrest.
"You cannot solve the problem without those countries which intervene in the problem. The stakeholders are the ones who sit down together to solve the problem," he said.
The Syrian government accuses the governments of Saudi Arabia and Turkey of arming insurgents in the country.
The Egyptian president said that he seeks to hold a meeting with the leaders of the three other states in the Syria group on the sidelines of UN General Assembly meeting in New York to discuss the Syria unrest.
Syria has been experiencing unrest since March 2011. Damascus says outlaws, saboteurs, and armed terrorists are the driving factor behind the deadly unrest while the opposition accuses the security forces of being behind the violence.
The Syrian government says that the chaos is being orchestrated from outside the country, and there are reports that a very large number of the armed militants are foreign nationals, mostly from Egypt, Algeria, Saudi Arabia, and Afghanistan.